![]() ![]() Louis County in 1877, becoming an independent city and limiting its political boundaries. Louis developed as a major port on the Mississippi River from 1870 until the 1920 census, it was the fourth-largest city in the country. The city was the point of embarkation for the Corps of Discovery on the United States' sponsored Lewis and Clark Expedition to explore the Louisiana Purchase. Three years later, Napoleon gave up on North America and sold the territory to the United States as part of the Louisiana Purchase. In 1800, Spain retroceded Louisiana to France. It ceded its nominal claim to areas west of the river to Spain. In 1764, France was defeated in the Seven Years' War and was forced to cede its territory east of the Mississippi to Great Britain. They named it for king Louis IX of France, and it quickly became the regional center of the French Illinois Country. Maxent, Pierre Laclède and Auguste Chouteau, all from New Orleans. Louis was founded on February 14, 1764, by French fur traders Gilbert Antoine de St. From roughly 900 to 1500 CE, it was a regional center of Mississippian culture, based in Cahokia east of the river, and extending across the continent along the Mississippi and its tributaries. It is the largest metropolitan area in Missouri and the second largest in Illinois.īefore European settlement, the area had been occupied for thousands of years by various Native American cultures. In 2020, the city proper had a population of 301,578, while its bi-state metropolitan area, which extends into Illinois, had an estimated population of over 2.8 million. It is located near the confluence of the Mississippi and the Missouri rivers. Louis ( / s eɪ n t ˈ l uː ɪ s, s ən t ˈ l uː ɪ s/) is the second-largest city in Missouri, United States.
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